Johnson City has a robust, $1 billion healthcare industry. It features several hospitals, medical centers, and clinics available for the community. The largest healthcare provider in the area is Ballad Health, which operates several hospitals and medical centers in the region, including Johnson City Medical Center, Franklin Woods Community Hospital, and Niswonger Children's Hospital.

There’s also James H. Quillen Department of Veterans Affairs Medical Center (one of the largest veterans hospitals in the Southeast) and the Mountain Home VA Hospital.

Other major healthcare providers in Johnson City include Mountain States Health Alliance, which operates Johnson City Specialty Hospital and Indian Path Community Hospital, as well as numerous clinics and medical practices.

 In addition to these large providers, there are also several independent clinics and practices in the area that provide a variety of medical services, including primary care, specialty care, and urgent care.